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45 W. 21st St. Second Floor Office Rental

  • Usage: Office
  • Type: Direct Lease
  • Floor: 2nd Floor
  • Size: 3,000 SQFT
  • Price: Request Price
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    Contact us for current pricing.

    Most NYC landlord restrict us from listing the asking rental price.

    Many landlords are offering significant concessions, construction allowances, and free rent.

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  • Term: Negotiable
Positioned in the vibrant heart of the Flatiron District, this full-floor, 3,000-square-foot office suite on the second floor of 45 West 21st Street blends historical charm with contemporary finishes. The space is defined by high 10’6” ceilings, beautifully refinished hardwood floors, and a bank of full-height, double-hung windows that flood the front-facing exposure with natural light and offer a view over a classic NoMad streetscape. With oversized windows lining two sides of the space, light reaches deep into the interior, illuminating a bright, open layout anchored by a newly constructed kitchen featuring modern cabinetry, stainless steel appliances, and a stone countertop backsplash.

The layout is a seamless balance between open collaboration and enclosed focus areas. At the front of the suite, a wide-open bullpen area accommodates up to 20 workstations with flexibility for team huddles, touchdown desks, or additional lounge seating. Along the side walls, four private perimeter rooms enclosed in floor-to-ceiling glass offer dedicated space for executive offices, breakout zones, or clinical use such as exam rooms or consultation suites. One additional room, currently configured as a glass-walled conference room, sits toward the interior core and provides a dedicated venue for client meetings, team briefings, or virtual calls. The suite maintains a clean visual line throughout, enhanced by the open ductwork, exposed piping, and polished industrial lighting that emphasize the building’s early 20th-century construction while embracing a modern aesthetic.

As a partial 2nd floor front suite, the space benefits from privacy without isolation and is ideal for tenants looking to project professionalism with architectural integrity. The unit is serviced by a keyed elevator and is equipped with central air conditioning. Ownership is willing to furnish the space for tenants committing to a five-year lease term. With close proximity to major subway lines and steps from Madison Square Park, this listing is a standout opportunity for creative firms, boutique agencies, or medical groups seeking an authentic, full-floor identity in one of Manhattan’s most desirable neighborhoods.


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45 W. 21st St., New York, NY 10010
Building at 45 W 21 St

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